Development and Characterization of novel bigel of loxoprofen for topical drug delivery

Bigels are unique two-phase systems that have recently been presented as a structured method for active ingredient application. The purposes of the current study were to develop and characterize bigel formulations containing loxoprofen. They benefits both hydrogel organo-gel. In order enhance penetration, pluronic lecithin was added form organo-gel, HPMC hydrogel, which properly hydrates stratum corneum. produced by mixing with organo-gel in appropriate ratio. pH, viscosity, extrudability, spreadability, Gel-sol transition temperature assessed hydrogel. For preparation bigel, O3 from H3 characterized optimum formulations. temperature, other properties assessed. An 8-hour invitro drug release investigation yielded B1's results, 84.77%. B2 demonstrated 92.35 % release, B3 99.18% extended-release. Based on evaluation characteristics, formulation chosen optimal formulation. Loxoprofen kinetics according Higuchi model. You can utilize loxoprofen an extended-release system.
 Keywords: Loxoprofen, (B)Bigel Pluronic F127, (O)Organo-gel, HPMC, Gel-sol, (H)Hydrogel